Unknown author2024-11-012024-11-012023-08-22https://eresearch.qmu.ac.uk/handle/20.500.12289/13953BACKGROUND: Human Papillomavirus vaccination (HPV) is an effective means of controlling cervical cancer, one of the leading causes of cancer-related deaths in Nigeria. The past decade has seen the implementation of national HPV vaccination programmes across sub-Saharan African countries. This review aims to explore the deterring and driving factors of awareness and acceptance of HPV vaccination in Nigeria, and the lessons and challenges from implementation of HPV vaccination programmes in the WHO African region. METHODS: This narrative review employed and adapted two search strategies to each selected electronic database: African Index Medicus, Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus, Medline, Livivo, PubMed, ProQuest, and Scopus. They were geared towards capturing the various expressions of driving and deterring factors of HPV vaccination awareness, acceptance, and lessons of pilot and national HPV implementation programmes in the WHO African Region. Zotero and Rayyan Software applications were used for the management of data. RESULTS: 40 articles were included in this review. Awareness of HPV vaccination was generally poor but willingness to accept HPV vaccination was high. Deterring factors were lack of information, fear of adverse effects, concerns about promiscuity, cultural and religious beliefs, and cost of the vaccine. Driving factors included: health education, and recommendation by health professionals, family, and friends. Massive awareness campaigns, integrated service delivery, community advocacy were success stories. Challenges included insufficient and inadequately trained healthcare workers, improper planning, and media/religious propaganda. CONCLUSION: It is necessary to address the barriers to HPV vaccine awareness and adopt the lessons from the WHO African Region.Thesis