CC BY 4.0 Attribution 4.0 International DeedGreenwood, Sharlene A.Briggs, JulietWalklin, ChristyMangahis, EmmanuelYoung, Hannah ML.Castle, Ellen M.Billany, Roseanne E.Asgari, ElhamBhandari, SunilBishop, NicoletteBramham, KateBurton, James O.Campbell, JackieChilcot, JosephCooper, NicolaDeelchand, VashistGraham-Brown, Matthew PM.Haggis, LyndaHamilton, AlexanderJesky, MarkKalra, Philip A.Koufaki, PelagiaMcCafferty, KieranNixon, Andrew C.Noble, HelenSaynor, Zoe L.Taal, Maarten W.Tollitt, JamesWheeler, David C.Wilkinson, Thomas J.Worboys, HannahMacdonald, Jamie2024-09-092024-09-092024-09-02Greenwood, S.A., Briggs, J., Walklin, C., Mangahis, E., Young, H.M.L., Castle, E.M., Billany, R.E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J.O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M.P.M., Haggis, L., Hamilton, A., Jesky, M., Kalra, P.A., Koufaki, P., McCafferty, K., Nixon, A.C., Noble, H., Saynor, Z.L., Taal, M.W., Tollitt, J., Wheeler, D.C., Wilkinson, T.J., Worboys, H. and Macdonald, J. (2024) ‘Kidney beam-a cost-effective digital intervention to improve mental health’, Kidney International Reports, 9(11), pp. 3204–3217. Available at: https://doi.org/10.1016/j.ekir.2024.08.030.https://eresearch.qmu.ac.uk/handle/20.500.12289/13846https://doi.org/10.1016/j.ekir.2024.08.030From Elsevier via Jisc Publications RouterHistory: accepted 2024-08-27, issued 2024-09-02AM replaced with VoR 2024-11-27Background There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention in CKD. Methods In a single-blind, 11 centre, randomised controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity digital health intervention or a waitlist control. This study assesses the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6 months, and cost-effectiveness of the intervention. Results At 6 months there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 {95% confidence interval: 4.4 to 7.5} arbitrary units, p<0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion The Kidney BEAM physical activity digital health intervention is a clinically valuable and cost-effective means to improve mental health related quality of life in people with CKD (trial registration no. NCT04872933).3204–3217Licence for AM version of this article starting on 2024-08-28: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.http://creativecommons.org/licenses/by/4.0/deed.enarticle2024-09-05