Browsing by Person "Fielding, K. L."

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Cost of point-of-care lateral flow urine lipoarabinomannan antigen testing in HIV-positive adults in South Africa
(International Union Against Tuberculosis and Lung Disease, 2018-09-01) Mukora, R.; Tlali, M.; Monkwe, S.; Charalambous, S.; Karat, Aaron S.; Fielding, K. L.; Grant, A. D.; Vassall, A.
INTRODUCTION: The World Health Organization recommends point-of-care (POC) lateral flow urine lipoarabinomannan (LF-LAM) for tuberculosis (TB) diagnosis in selected human immunodeficiency virus (HIV) positive people. South Africa had 438 000 new TB episodes in 2016, 58.9% of which were contributed by HIV-positive people. LF-LAM is being considered for scale-up in South Africa.
An intervention to optimise the delivery of integrated tuberculosis and HIV services at primary care clinics: Results of the MERGE cluster randomised trial
(Elsevier, 2018-07-25) Kufa, T.; Fielding, K. L.; Hippner, P.; Kielmann, Karina; Vassall, A.; Churchyard, G. J.; Grant, A. D.; Charalambous, S.
Objectives: To evaluate the effect of an intervention to optimize TB/HIV integration on patient outcomes.
Lessons learnt conducting minimally invasive autopsies in private mortuaries as part of HIV and tuberculosis research in South Africa
(International Union Against Tuberculosis and Lung Disease, 2019-12-21) Karat, Aaron S.; Omar, T.; Tlali, M.; Charalambous, S.; Chihota, V. N.; Churchyard, G. J.; Fielding, K. L.; Martinson, N. A.; McCarthy, K. M.; Grant, A. D.
Current estimates of the burden of tuberculosis (TB) disease and cause-specific mortality in human immunodeficiency virus (HIV) positive people rely heavily on indirect methods that are less reliable for ascertaining individual-level causes of death and on mathematical models. Minimally invasive autopsy (MIA) is useful for diagnosing infectious diseases, provides a reasonable proxy for the gold standard in cause of death ascertainment (complete diagnostic autopsy) and, used routinely, could improve cause-specific mortality estimates. From our experience in performing MIAs in HIV-positive adults in private mortuaries in South Africa (during the Lesedi Kamoso Study), we describe the challenges we faced and make recommendations for the conduct of MIA in future studies or surveillance programmes, including strategies for effective communication, approaches to obtaining informed consent, risk management for staff and efficient preparation for the procedure.