Browsing by Person "Harrison, Anthony"

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Efficacy of targeted versus non-targeted exercise and behavioural interventions on fatigue in multiple sclerosis: systematic review and meta-analysis
(PROSPERO, 2016-08-22) Moss-Morris, Rona; Mercer, Tom; White, Claire; van der Linden, Marietta; Thomas, Sarah; Harrison, Anthony; Safari, Reza; Norton, Sam
Review question(s) The specific objectives are to: (1) Provide a narrative synthesis of all the interventions, including a summary of the nature of the intervention using the Template for intervention Description and Replication (TiDieR), and assessment of study quality (risk of bias), alongside the standardised intervention effect sizes. As a detailed synthesis already includes studies evaluating interventions specifically targeting MS fatigue (ref: CRD42016033763), the narrative synthesis will focus on studies evaluating interventions that (a) do not specifically target fatigue, or (b) measured fatigue as a secondary outcome. (2) Conduct (pair-wise) meta-analyses to pool effect sizes across intervention types (exercise, behavioural, mixed) and estimate statistical heterogeneity. (3) Directly compare specific types of targeted versus non-targeted exercise, behavioural and combined interventions on fatigue in multiple sclerosis, using network meta-analyses. (4) Conduct exploratory moderator and sensitivity analyses to explore how treatment effects vary according to health care professional (HCP) contact, type of MS, and study quality (i.e. risk of bias).
Which exercise or behavioural fatigue interventions are effective for people with multiple sclerosis (MS)? A systematic review with detailed intervention breakdown and meta-analysis
(PROSPERO, 2016-06-01) Moss-Morris, Rona; Mercer, Tom; White, Claire; Thomas, Sarah; van der Linden, Marietta; Harrison, Anthony; Safari, Reza; Norton, Sam
Review question(s) The overall aim of this review is to provide guidance as to which of the existing exercise and behavioural interventions appear most promising for the treatment of MS fatigue. The specific objectives are to: (1) Provide a narrative synthesis of all the interventions including a breakdown of the key contextual and treatment components of each of the interventions, the acceptability of the interventions (uptake and adherence), and the study quality (risk of bias) alongside the standardized intervention effect sizes. (2) Conduct meta-analyses of effect sizes across interventions with similar key intervention components. (3) Compare the overall effect sizes of the exercise and behavioral interventions followed by subgroup analysis within each of these groups (e.g. behavioral interventions: energy conservation, CBT, combined; exercise interventions: aerobic endurance, strength, balance and combined). (4) Conduct exploratory moderator and sensitivity analyses to explore how treatment effects vary according to whether interventions were guided by theory or not, different levels of health care professional contact (e.g. email support, telephone, face-to-face), types of MS, comparators used, and study quality.