Browsing by Person "Storey, D. J."

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Clinically relevant fatigue in cancer outpatients: the Edinburgh Cancer Centre symptom study
(2007-09-05) Storey, D. J.; Waters, Rachael A.; Hibberd, Carina J.; Rush, Robert; Cargill, A.; Wall, L. R.; Fallon, Marie T.; Strong, V.; Walker, J.; Sharpe, M.
Background: Fatigue is associated with cancer and its treatment but we know little about how many and which patients suffer fatigue of clinical severity. We aimed to determine the prevalence of clinically relevant fatigue (CRF) and its associations in outpatients with various cancer diagnoses. Patients and methods: A survey of outpatients with colorectal, breast, gynaecological, genitourinary, sarcoma, melanoma and miscellaneous tumours at a regional cancer centre. Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) fatigue subscale and the Hospital Anxiety and Depression Scale (HADS). These self-report data were linked to demographic and clinical variables. Data were available on 2867 outpatients. Results: The prevalence of CRF (EORTC fatigue subscale ‡40) was 32% (95% confidence interval 31–34%). The variables independently associated with CRF were primary cancer site, having disease present, type of cancer treatment and emotional distress (total HADS score ‡15). Emotional distress had the strongest association with fatigue but half the cases of CRF were not distressed. Conclusion: CRF is common in cancer outpatients and is associated with type of disease and treatment, as well as with emotional distress. The association between CRF and emotional distress is strong but they are not equivalent conditions. Key words: associations, cancer, fatigue, predictors, prevalence, treatment
Emotional distress in cancer patients: the Edinburgh Cancer Centre symptom study
(2007-02-20) Strong, V.; Waters, Rachael A.; Hibberd, Carina J.; Rush, Robert; Cargill, A.; Storey, D. J.; Walker, J.; Wall, L.; Fallon, Marie T.; Sharpe, M.
To: (1) estimate the prevalence of clinically significant emotional distress in patients attending a cancer outpatient department and (2) determine the associations between distress and demographic and clinical variables, we conducted a survey of outpatients attending selected clinics of a regional cancer centre in Edinburgh, UK. Patients completed the Hospital Anxiety and Depression Scale (HADS) on touch-screen computers and the scores were linked to clinical variables on the hospital database. Nearly one quarter of the cancer outpatients 674 out of 3071 (22%; 95% confidence interval (CI) 20–23%) met our criterion for clinically significant emotional distress (total HADS score 15 or more). Univariate analysis identified the following statistically significant associations: age <65, female gender, cancer type and extent of disease. Multivariate analysis indicated that age <65 (odds ratio 1.41; 95% CI 1.18–1.69), female gender (odds ratio 1.58; 95% CI 1.31–1.92) and active disease (odds ratio 1.72; 95% CI 1.43–2.05) but not cancer diagnosis, were the independent predictors of clinically significant emotional distress. Services to treat distress in cancer patients should be organised to target patients by characteristics other than their cancer diagnosis.
Endometrioid epithelial ovarian cancer: 20 Years of prospectively collected data from a single center
(American Cancer Society, 2008-05-15) Storey, D. J.; Rush, Robert; Stewart, Moira; Rye, Tzyvia; Al-Nafussi, Awatif; Williams, Alistair R.; Smyth, John F.; Gabra, Hani