Browsing by Person "Villar, Alice"

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Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis
(Springer, 2024-04-19) Villar, Alice; Paladini, Stefania; Cossatis, J
Evidence This study investigated the relationship between periodontal disease (PD) and Alzheimer’s Disease (AD) through a Systematic Literature Network Analysis (SLNA), combining bibliometric analysis with a Systematic Literature Review (SLR). Analyzing 328 documents from 2000 to 2023, we utilized the Bibliometrix R-package for multiple bibliometric analysis. The SLR primarily centered on the 47 most globally cited papers, highlighting influential research. Our study reveals a positive correlation between Periodontal Disease (PD) and Alzheimer’s Disease (AD), grounded in both biological plausibility and a comprehensive review of the literature, yet the exact causal relationship remains a subject of ongoing scientific investigation. We conducted a detailed analysis of the two main pathways by which PD could contribute to brain inflammation: (a) the Inflammatory Cascade, and (b) Microbial Involvement. The results of our SLNA emphasize the importance of oral health in reducing Alzheimer’s risk, suggesting that managing periodontal health could be an integral part of Alzheimer’s prevention and treatment strategies. The insights from this SLNA pave the way for future research and clinical practices, underscoring the necessity of interdisciplinary methods in both the investigation and treatment of neurodegenerative diseases like Alzheimer’s. Furthermore, our study presents a prospective research roadmap to support ongoing advancement in this field.
Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis [Dataset]
(2024-04-19) Villar, Alice; Paladini, Stefania; Cossatis, João
Supplementary data for: Villar, A., Paladini, S. and Cossatis, J. (2024) ‘Periodontal disease and Alzheimer’s: insights from a systematic literature network analysis’, The Journal of Prevention of Alzheimer’s Disease, 11(4), pp. 1148–1165. Available at: https://doi.org/10.14283/jpad.2024.79 is available at: https://github.com/alicevillar/SLNA_PD-AD .
The relationship between periodontal disease and cancer: Insights from a Systematic Literature Network Analysis
(Elsevier, 2024-06-14) Villar, Alice; Mendes, Bruna; Viègas, Mirna; de Aquino Alexandre, Ana Léa; Paladini, Stefania; Cossatis, João
This paper investigates the relationship between periodontal disease and various cancer types. It provides a comprehensive overview of the existing knowledge about the interaction between periodontal disease and carcinogenesis, explores the underlying biological mechanisms of this connection, and consider the impact of these findings on healthcare practices and future research directions. Utilizing Systematic Literature Network Analysis, which combines bibliometric analysis with Systematic Literature Review, this study analyzes 164 documents from 2000 to 2023. Focus is placed on the 38 most globally cited papers, enabling a targeted and comprehensive analysis of the predominant research within this scope. This review highlights that colorectal, oral, pancreatic, lung, and gastrointestinal cancers have consistent associations with periodontal disease. On the other hand, hematological, breast and prostate cancers show associations with periodontal disease, but these links are less pronounced and more variable, indicating the need for targeted research in these domains. These insights emphasize the necessity for a multidisciplinary healthcare approach, recognizing the systemic implications of periodontal disease. © 2024 Elsevier Ltd
Towards Supply Chain 5.0: Redesigning Supply Chains as Resilient, Sustainable, and Human-Centric Systems in a Post-pandemic World
(Springer International Publishing, 2023-07-29) Villar, Alice; Paladini, Stefania; Buckley, Oliver
The purpose was to investigate the impact of the Industry 5.0 paradigm on the supply chain research field. Our study contributes to the conceptualization of supply chain 5.0, a term that has been receiving increased attention as supply chains adapt to the fifth industrial revolution. We conducted a systematic literature network analysis (SLNA) to examine the research landscape of Industry 5.0 supply chains. We used VOSViewer software and Bibliometrix R-package for multiple bibliometric analyses using 682 documents published between 2016 and 2022. We present a comprehensive framework of supply chain 5.0, including its key concepts, technologies, and trends. Additionally, this research offers a future research agenda to inspire and support further development in this field. We utilized three academic databases for bibliometric analyses: Dimension, Scopus and Lens. Additional databases could provide a wider research landscape and better field representation. We demonstrate how Industry 5.0 enables supply chain evaluation and optimization to assist companies in navigating disruptions without compromising competitiveness and profitability and provide a unique contribution to the field of supply chain 5.0 by exploring promising research areas and guiding the transition to this new paradigm for practitioners and scholars.