Browsing by Person "Prowse, Christopher"
Now showing 1 - 1 of 1
- Results Per Page
- Sort Options
Item Molecular Model of Prion Transmission to Humans(Centers for Disease Control and Prevention, 2009-12) Jones, Michael; Wight, Darren; Barron, Rona; Jeffrey, Martin; Manson, Jean; Prowse, Christopher; Ironside, James W.; Head, Mark W.To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.