Molecular Model of Prion Transmission to Humans
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Date
2009-12
Citation
Jones, M., Wight, D., Barron, R., Jeffrey, M., Manson, J., Prowse, C., Ironside, J.W. and Head, M.W. (2009) ‘Molecular model of prion transmission to humans’, Emerging Infectious Diseases, 15(12), pp. 2013–2016. Available at: https://doi.org/10.3201/eid1512.090194.
Abstract
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.