Molecular Model of Prion Transmission to Humans
| dc.contributor.author | Jones, Michael | en |
| dc.contributor.author | Wight, Darren | en |
| dc.contributor.author | Barron, Rona | en |
| dc.contributor.author | Jeffrey, Martin | en |
| dc.contributor.author | Manson, Jean | en |
| dc.contributor.author | Prowse, Christopher | en |
| dc.contributor.author | Ironside, James W. | en |
| dc.contributor.author | Head, Mark W. | en |
| dc.date.accessioned | 2022-12-20T15:38:49Z | |
| dc.date.available | 2022-12-20T15:38:49Z | |
| dc.date.issued | 2009-12 | |
| dc.description | Rona Barron - ORCID: 0000-0003-4512-9177 https://orcid.org/0000-0003-4512-9177 | en |
| dc.description.abstract | To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility. | en |
| dc.description.ispublished | pub | |
| dc.description.number | 12 | en |
| dc.description.status | pub | |
| dc.description.uri | https://doi.org/10.3201%2Feid1512.090194 | en |
| dc.description.volume | 15 | en |
| dc.format.extent | 2013-2016 | en |
| dc.identifier.citation | Jones, M., Wight, D., Barron, R., Jeffrey, M., Manson, J., Prowse, C., Ironside, J.W. and Head, M.W. (2009) ‘Molecular model of prion transmission to humans’, Emerging Infectious Diseases, 15(12), pp. 2013–2016. Available at: https://doi.org/10.3201/eid1512.090194. | en |
| dc.identifier.uri | https://eresearch.qmu.ac.uk/handle/20.500.12289/12719 | |
| dc.identifier.uri | https://doi.org/10.3201%2Feid1512.090194 | |
| dc.language.iso | en_US | en |
| dc.publisher | Centers for Disease Control and Prevention | en |
| dc.relation.ispartof | Emerging Infectious Diseases | en |
| dc.rights | This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. | |
| dc.title | Molecular Model of Prion Transmission to Humans | en |
| dc.type | Article | en |
| rioxxterms.type | Journal Article/Review | en |
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