Repository logo
 

Dietetics, Nutrition and Biological Sciences

Permanent URI for this collectionhttps://eresearch.qmu.ac.uk/handle/20.500.12289/23

Browse

Author: search.filters.author.Vasilaki, KaterinaSubject: search.filters.subject.Albumin

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    The relationship between plasma and red cell B-vitamin concentrations in critically-ill patients
    (Elsevier, 2005-07-28) Quasim, Tara; McMillan, Donald C.; Talwar, Dinesh; Vasilaki, Katerina; O'Reilly, Denis St J.; Kinsella, John
    Background and aims: Low vitamin B-complex status has been associated with poorer outcome in critically-ill patients. However, these findings have been based on indirect methods. Using direct methods for assessing vitamin status, we examined the effect of B-complex vitamin supplementation by measuring plasma and red blood cell B1, B2 and B6-vitamin concentrations in critically-ill patients. Methods: Thiamine diphosphate (TDP), flavin adenine dinucleotide (FAD) and pyridoxal phosphate (PLP) concentrations were measured in plasma and red cells of normal subjects (n ¼ 49) and ITU patients (n ¼ 41). Results: Compared with the normal subjects, critically-ill patients had higher C- reactive protein and lower albumin concentrations (Po0:001). Also, plasma FAD and PLP were lower (Po0:001) and red cell concentrations of both were higher (Po0:01) in critically-ill patients. Critically-ill patients were grouped according to whether (n ¼ 23) or not (n ¼ 18) they had been supplemented with B-complex vitamins. Compared with non-supplemented group, the supplemented group had significantly higher red cell TDP and PLP concentrations (Po0:01). Plasma FAD and PLP concentrations did not differ significantly between the groups. Conclusions: The results of the present study suggest that direct measurements of red cell FAD and PLP are more responsive to supplementation than plasma measurements in the critically-ill patient.
  • No Thumbnail Available
    Item
    The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin
    (Elsevier, 2015-02-26) Ghashut, Rawia A.; McMillan, Donald C.; Kinsella, John; Vasilaki, Katerina; Talwar, Dinesh; Duncan, Andrew
    Background & aim: The magnitude of systemic inflammatory response, as evidenced by C-reactive protein (CRP), is a major factor associated with lower zinc and selenium. They may also be influenced by their binding proteins, such as albumin. The aim of the present study was to examine the relationships between plasma zinc, selenium and the systemic inflammatory response in a large cohort of patients referred for nutritional screen and also to examine these relationships in patients with critical illness. Methods: Patients referred for nutritional assessment of zinc (n ¼ 743) and selenium (n ¼ 833) and 114 patients with critical illness were examined. Intra-assay imprecision was <10% for these analytes. Results: In the nutritional screen cohort, plasma zinc was significantly associated with CRP (rs ¼ 0.404, p < 0.001) and albumin (rs ¼ 0.588, p < 0.001). For each CRP category ( 10, 11e80, >80 mg/l) the zinc/ albumin ratio x100 was similar (31, 33 and 32 respectively, p ¼ 0.029). Plasma selenium was significantly associated with CRP (rs ¼ 0.489, p < 0.001) and albumin (rs ¼ 0.600, p < 0.001). With increasing CRP category ( 10, 11e80, >80 mg/l) the selenium/albumin ratio 100 was lower (2.3, 2.1 and 1.8 respec- tively, p < 0.001). Similar relationships were also observed in the cohort of patients with critical illness. Conclusion: Plasma zinc was associated with both CRP and albumin. The impact of the systemic in- flammatory response could be largely adjusted by albumin concentrations. Plasma selenium was asso- ciated with both CRP and albumin. The impact of the systemic inflammatory response on plasma selenium concentrations could not be reasonably adjusted by albumin concentrations.