Repository logo
 

eTheses

Permanent URI for this communityhttps://eresearch.qmu.ac.uk/handle/20.500.12289/7180

This community contains an online collection of PhD theses and selected undergraduate and postgraduate dissertations written by QMU students and researchers.

PhD theses are available to be browsed, searched, read or printed by anyone interested in their content.

Undergraduate and postgraduate dissertations in are only available to be read or printed by registered QMU staff and students (login required).

Contact Us

If you have any items to add or if you have any queries or comments about this repository or its contents, please contact eResearch@qmu.ac.uk.

Click on a link below to browse or search collections.

Browse

Filters

20241

Settings

Author: search.filters.author.Adamson, SusanStart date: 2020

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    ​A RETROSPECTIVE CLINICAL AUDIT OF THE CLINICAL APPLICATION OF THE RAYPILOT REAL TIME MOTION MANAGEMENT SYSTEM AND THE FEASABILITY OF ITS USE FOR FURTHER DOSE ESCALATED STEREOTACTIC BODY RADIOTHERAPY FOR PROSTATE CANCER.
    (Queen Margaret University, Edinburgh, 2024-03-13) Adamson, Susan
    ​Background and purpose ​Prostate cancer is one of the most prevalent malignancies within oncology cases. Intrafraction motion is an important consideration in the clinical delivery of radiotherapy and indeed, long-term outcome and toxicity for patients. The purpose of this retrospective clinical audit was to review the efficacy of the RayPilot® real time motion management system and the impact that this has on planning target margins in prostate stereotactic body radiotherapy to assess if the RayPilot® system could be used clinically to allow for further dose escalation and fractionation reduction. ​Materials and methods ​Intrafraction motion was measured and recorded using the RayPilot® real time motion management system in seven patients. The RayPilot® system collated intrafraction data thirty times per second during treatment delivery for each patient. The collected data was then used to replan the patient in the Eclipse treatment planning software using reduced planning target margins to assess if this was a feasible method of dose escalation by reducing treatment fractionation. ​Results ​The RayPilot® recorded data resulted in 54175 intrafraction motion measurements in total. Mean displacement (following removal of outliers >0.3cm) was 0.1cm (SD± 0.1cm), 0.1cm (SD± 0.1cm) and 0.1cm (SD± 0.1cm) in the lateral, longitudinal and vertical directions respectively. The Van Herk Margin recipe was used to calculate the required clinical margins using the intrafraction motion data resulting in lateral, longitudinal and vertical margins of 0.7cm, 0.7cm and 0.7cm respectively. These margins allowed for dose escalation of 2400cGy in three fractions with no detrimental effects or increase in patient toxicity using dose volume histogram analysis. ​Conclusion ​RayPilot® is an efficient method of monitoring and recording prostate intrafraction motion and allowed for a reduction in target volume margins resulting in dose escalation in prostate stereotactic body radiotherapy. However, further analysis and research must be carried out to assess the feasibility of it being used as a stand-alone monitoring modality.

This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.