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This community contains an online collection of PhD theses and selected undergraduate and postgraduate dissertations written by QMU students and researchers.

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Author: search.filters.author.Siddiqui, Muhammad A.

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    Development of a prognostic model for fistula maturation in patients with advanced renal failure
    (Queen Margaret University, Edinburgh, 2014) Siddiqui, Muhammad A.
    A suitable type of vascular access has to be created to establish a connection between the circulation system of the patient and the haemodialysis cycle. The arteriovenous fistula (AVF) is considered to provide the best long-term functional vascular access, with reduced risk of thrombosis or infection and cost-effective. However, significant numbers of AVF, which fail to develop sufficiently for dialysis, are 28-53% of cases. This study aimed to explore the potential influence of blood markers and factors on the maturation of AVF, in patients who have undergone vascular access surgery and to develop and validate a prognostic model to determine the success of AVF maturation.
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    Drug treatments for high cholesterol blood levels, with Atorvastatin versus Simvastatin: A Systematic review and Meta-analysis
    (Queen Margaret University, 2008-08) Siddiqui, Muhammad A.
    Objectives: Diabetes mellitus is a strong risk factor for atherosclerosis and is often characterized by hyperlipidemia. This review was done to evaluate the effectiveness of pharmacological management of hyperlipidemia with atorvastatin versus simvastatin in lowering high cholesterol among diabetic and cardiac patients. Sources: Trials were identified by searching four electronic databases (Medline, Cochrane, Pub Med, Scopus and Highwire) and the reference lists of eligible publications. Keywords: Dyslipidemia, statins and diabetes, atheroscelerosis, statins, atorvastatin, simvastatin Methods: We performed a systematic review of trials that randomly assigned participants to receive atorvastatins versus simvastatin or simvastatin versus placebo or atorvastatin versus placebo for a minimum of 6 week. A meta-analysis was performed using a fixed-effects model, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate pooled treatment effects. All statistical tests were two sided. Revman 5.0 version have been used to assess the difference between two treatment group. Result: Thirteen trials were included, involving a total of 20598 participants. Trials differed considerably in their inclusion criteria; outcomes measured, and type of lipid-lowering therapy used. The pooled results from all eligible trials indicated that atorvastatin therapy had no statistically significant effect than simvastatin on overall mortality (Risk Ratio (RR) 0.88; 95% confidence Interval (CI) 0.34 to 2.27; P = 0.78)) or on total cardiovascular events (RR 0.99; 95% CI 0.69 to 1.42, P = 0.95). However, analysis showed that atorvastatin significantly reduced the total blood cholesterol versus simvastatin (RR 0.74; CI 0.55 to 0.98). This was primarily due to a positive effect on total coronary events (RR 8.24; 95%CI 8.18 to 8.29; P < 0.00001). Greatest evidence of effectiveness came from the use of atorvastatin in people with blood cholesterol 3.5 mmol/litre. Conclusion: The role of statin therapy as a main component of cardiovascular risk reduction in-patients with diabetes. Atorvastatin have significantly better outcomes in lowering blood cholesterol against simvastatin but there was no significant difference in the mortality and total cardiovascular events.

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