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    Lessons learnt conducting minimally invasive autopsies in private mortuaries as part of HIV and tuberculosis research in South Africa

    Date
    2019-12-21
    Author
    Karat, Aaron S.
    Omar, T.
    Tlali, M.
    Charalambous, S.
    Chihota, V. N.
    Churchyard, G. J.
    Fielding, K. L.
    Martinson, N. A.
    McCarthy, K. M.
    Grant, A. D.
    Metadata
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    Citation
    Karat, A. S., Omar, T., Tlali, M., Charalambous, S., Chihota, V. N., Churchyard, G. J., Fielding, K. L., Martinson, N. A., McCarthy, K. M. & Grant, A. D. (2019) Lessons learnt conducting minimally invasive autopsies in private mortuaries as part of HIV and tuberculosis research in South Africa. Public Health Action, 9(4), pp. 186-190.
    Abstract
    Current estimates of the burden of tuberculosis (TB) disease and cause-specific mortality in human immunodeficiency virus (HIV) positive people rely heavily on indirect methods that are less reliable for ascertaining individual-level causes of death and on mathematical models. Minimally invasive autopsy (MIA) is useful for diagnosing infectious diseases, provides a reasonable proxy for the gold standard in cause of death ascertainment (complete diagnostic autopsy) and, used routinely, could improve cause-specific mortality estimates. From our experience in performing MIAs in HIV-positive adults in private mortuaries in South Africa (during the Lesedi Kamoso Study), we describe the challenges we faced and make recommendations for the conduct of MIA in future studies or surveillance programmes, including strategies for effective communication, approaches to obtaining informed consent, risk management for staff and efficient preparation for the procedure.
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/10361
    Official URL
    https://doi.org/10.5588/pha.19.0032
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