Exercise-induced changes in gait kinematics in multiple sclerosis with minimal neurological disability
Guerrero Enriquez, Julia
Mahad, Don J.
van der Linden, Marietta
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Andreopoulou, G., Mercer, T., Guerrero Enriquez, J., Justin, M., MacLeod, N., Harrison, E., Mahad, D. J. & van der Linden, M. (2020) Exercise-induced changes in gait kinematics in multiple sclerosis with minimal neurological disability. Multiple Sclerosis and Related Disorders, 47:102630.
Background Exercise-induced gait deterioration is a frequently encountered symptom that limits ambulation throughout the clinical course, becoming more prominent with increasing neurological disability in people with MS (pwMS).Objective We attempted to objectively document exercise-induced gait changes in pwMS with minimal neurological disability and stable disease.Methods Gait kinematics and spatio-temporal parameters were recorded using 3D motion analysis before and after a 20-minute treadmill walk (Group A, n=15)/run (Group B, n=15) at a self-selected speed in pwMS and compared with healthy controls (n=15).Results Gait analysis revealed a significant decrease in peak ankle dorsiflexion in swing of the most affected leg, post-exercise task, in both Group A (EDSS 2.5-3.5) and Group B (EDSS 1-2.5) and not in healthy controls. Fourteen out of 30 MS participants showed an exercise-induced gait deterioration, based on minimal detectable change. Pre-exercise gait parameters in Group A showed a significantly higher peak dorsiflexion in swing with shorter step length and higher cadence, whereas Group B was comparable to healthy controls.Conclusion The detection of exercise-induced gait deterioration (foot drop) in pwMS with minimal neurological disability and stable disease indicates the potential of gait kinematics, before and after an exercise task, to monitor subtle neurological deficits from an early stage of MS.