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    Membrane pathology and microglial activation of mice expressing membrane anchored or membrane released forms of Aβ and mutated human Alzheimer's precursor protein (APP)

    Date
    2014-08-18
    Author
    Jeffrey, Martin
    McGovern, Gillian
    Barron, Rona
    Baumann, Frank
    Metadata
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    Citation
    Jeffrey, M., McGovern, G., Barron, R. and Baumann, F. (2015) ‘Membrane pathology and microglial activation of mice expressing membrane anchored or membrane released forms of Aβ and mutated human Alzheimer’s precursor protein (App): Membrane pathology of anchored Aβ’, Neuropathology and Applied Neurobiology, 41(4), pp. 458–470. Available at: https://doi.org/10.1111/nan.12173.
    Abstract
    Alzheimer's disease and the transmissible spongiform encephalopathies or prion diseases accumulate misfolded and aggregated forms of neuronal cell membrane proteins. Distinctive membrane lesions caused by the accumulation of disease-associated prion protein (PrPd) are found in prion disease but morphological changes of membranes are not associated with Aβ in Alzheimer's disease. Membrane changes occur in all prion diseases where PrPd is attached to cell membranes by a glycosyl-phosphoinositol (GPI) anchor but are absent from transgenic mice expressing anchorless PrPd. Here we investigate whether GPI membrane attached Aβ may also cause prion-like membrane lesions.
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/12702
    Official URL
    https://doi.org/10.1111/nan.12173
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    • Dietetics, Nutrition and Biological Sciences

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