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    Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein

    Date
    2012-07-01
    Author
    Wilson, Rona
    Plinston, Chris
    Hunter, Nora
    Casalone, Cristina
    Corona, Cristiano
    Tagliavini, Fabrizio
    Suardi, SIlvia
    Ruggerone, Margherita
    Graziano, Silvia
    Sbriccoli, Marco
    Cardone, Franco
    Pocchiari, Maurizio
    Ingrosso, Loredana
    Baron, Thierry
    Richt, Juergen
    Andreoletti, Olivier
    Simmons, Marion
    Lockey, Richard
    Manson, Jean C.
    Barron, Rona
    Metadata
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    Citation
    Wilson, R., Plinston, C., Hunter, N., Casalone, C., Corona, C., Tagliavini, F., Suardi, S., Ruggerone, M., Moda, F., Graziano, S., Sbriccoli, M., Cardone, F., Pocchiari, M., Ingrosso, L., Baron, T., Richt, J., Andreoletti, O., Simmons, M., Lockey, R., Manson, J.C. and Barron, R.M. (2012) ‘Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein’, Journal of General Virology, 93(7), pp. 1624–1629. Available at: https://doi.org/10.1099/vir.0.042507-0.
    Abstract
    The association between bovine spongiform encephalopathy (BSE) and variant Creutzfeldt–Jakob disease (vCJD) has demonstrated that cattle transmissible spongiform encephalopathies (TSEs) can pose a risk to human health and raises the possibility that other ruminant TSEs may be transmissible to humans. In recent years, several novel TSEs in sheep, cattle and deer have been described and the risk posed to humans by these agents is currently unknown. In this study, we inoculated two forms of atypical BSE (BASE and H-type BSE), a chronic wasting disease (CWD) isolate and seven isolates of atypical scrapie into gene-targeted transgenic (Tg) mice expressing the human prion protein (PrP). Upon challenge with these ruminant TSEs, gene-targeted Tg mice expressing human PrP did not show any signs of disease pathology. These data strongly suggest the presence of a substantial transmission barrier between these recently identified ruminant TSEs and humans.
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/12711
    Official URL
    https://doi.org/10.1099/vir.0.042507-0
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    • Dietetics, Nutrition and Biological Sciences

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