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    The role of host PrP in Transmissible Spongiform Encephalopathy

    Date
    2007-06
    Author
    Cancellotti, Enrico
    Barron, Rona
    Bishop, Matthew T.
    Hart, Patricia
    Wiseman, Patricia
    Manson, Jean C.
    Metadata
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    Citation
    Cancellotti, E., Barron, R.M., Bishop, M.T., Hart, P., Wiseman, F. and Manson, J.C. (2007) ‘The role of host prp in transmissible spongiform encephalopathies’, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1772(6), pp. 673–680. Available at: https://doi.org/10.1016/j.bbadis.2006.10.013.
    Abstract
    PrP has a central role in the Transmissible Spongiform Encephalopathies (TSEs), and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent. However, precisely how host PrP influences the outcome of disease has not been established. To investigate this we have produced by gene targeting a series of inbred lines of transgenic mice expressing different PrP genes. This allows us to study directly the influence of the host PrP gene in TSEs. We have examined the role of glycosylation, point mutations, polymorphisms and PrP from different species on host susceptibility and the disease process both within the murine species and across species barriers.
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/12722
    Official URL
    https://doi.org/10.1016/j.bbadis.2006.10.013
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    • Dietetics, Nutrition and Biological Sciences

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