Queen Margaret University logo
    • Login
    View Item 
    •   QMU Repositories
    • eResearch
    • School of Health Sciences
    • The Institute for Global Health and Development
    • View Item
    •   QMU Repositories
    • eResearch
    • School of Health Sciences
    • The Institute for Global Health and Development
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Clinical characteristics and prognosis of patients admitted for heart failure: A 5-year retrospective study of African patients

    Date
    2017-07-01
    Author
    Bonsu, Kwadwo Osei
    Owusu, Isaac Kofi
    Buabeng, Kwame Ohene
    Reidpath, Daniel
    Kadirvelu, Amudha
    Metadata
    Show full item record
    Citation
    Bonsu, K.O., Owusu, I.K., Buabeng, K.O., Reidpath, D.D. and Kadirvelu, A. (2017) ‘Clinical characteristics and prognosis of patients admitted for heart failure: A 5-year retrospective study of African patients’, International Journal of Cardiology, 238, pp. 128–135. Available at: https://doi.org/10.1016/j.ijcard.2017.03.014.
    Abstract
    Background Mortality associated with heart failure (HF) remains high. There are limited clinical data on mortality among HF patients from African populations. We examined the clinical characteristics, long-term outcomes, and prognostic factors of African HF patients with preserved, mid-range or reduced left ventricular ejection fraction (LVEF). Methods and results We conducted a retrospective longitudinal cohort study of individuals aged ≥ 18 years discharged from first HF admission between January 1, 2009 and December 31, 2013 from the Cardiac Clinic, Directorate of Medicine of the Komfo Anokye Teaching Hospital, Ghana. A total of 1488 patients diagnosed of HF were included in the analysis. Of these, 345 patients (23.2%) had reduced LVEF (LVEF < 40%) [HFrEF], 265(17.8%) with mid-range LVEF (40% ≥ LVEF < 50%) [HFmEF] and 878 (59.0%) had preserved LVEF (LVEF ≥ 50%) [HFpEF]. Kaplan–Meier curves and log-rank test demonstrated better prognosis for HFpEF compared to HFrEF and HFmEF patients. An adjusted Cox analysis showed a significantly lower risk of mortality for HFpEF (hazard ratio (HR); 0.74; 95% confidence interval (CI) 0.57–0.94) p = 0.015). Multivariate analyses showed that age, higher New York Heart Association (NYHA) functional class, lower LVEF, chronic kidney disease, atrial fibrillation, anemia, diabetes mellitus and absence of statin and aldosterone antagonist treatment were independent predictors of mortality in HF. Although, prognostic factors varied across the three groups, age was a common predictor of mortality in HFpEF and HFmEF. Conclusions This study identified the clinical characteristics, long-term mortality and prognostic factors of African HF patients with reduced, mid-range and preserved ejection fractions in a clinical setting.
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/12906
    Official URL
    https://doi.org/10.1016/j.ijcard.2017.03.014
    Collections
    • The Institute for Global Health and Development

    Queen Margaret University: Research Repositories
    Accessibility Statement | Repository Policies | Contact Us | Send Feedback | HTML Sitemap

     

    Browse

    All QMU RepositoriesCommunities & CollectionsBy YearBy PersonBy TitleBy QMU AuthorBy Research CentreThis CollectionBy YearBy PersonBy TitleBy QMU AuthorBy Research Centre

    My Account

    LoginRegister

    Queen Margaret University: Research Repositories
    Accessibility Statement | Repository Policies | Contact Us | Send Feedback | HTML Sitemap