Investigating the inhibitory activity of green coffee and cacao bean extracts on pancreatic lipase
McDougall, G. J.
Al-Dujaili, Emad A. S.
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Almoosawi, S., McDougall, G., Fyfe, L. & Al-Dujaili, E. (2010) Investigating the inhibitory activity of green coffee and cacao bean extracts on pancreatic lipase, Nutrition Bulletin, vol. 35, , pp. 207-212,
The present study investigated the effects of green coffee bean extract and Theobroma cacao bean extract on pancreatic lipase activity in vitro. Green coffee bean extract produced a J-shaped dose-dependent inhibition of pancreatic lipase with the percentage inhibition of pancreatic lipase ranging from 11.8% to 61.5%. Similar concentrations of Theobroma cacao failed to produce any effect on pancreatic lipase. Non-linear regression analysis revealed that the concentration of green coffee bean extract required to elicit a 50% inhibition of pancreatic lipase activity (IC50) was approximately 43 _M. In conclusion, extracts of green coffee beans but not Theobroma cacao possess potent inhibitory activity against pancreatic lipase. 2010 The Authors. Journal compilation 2010 British Nutrition Foundation.