Effect of exercise interventions on perceived fatigue in people with multiple sclerosis: synthesis of meta-analytic reviews
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Date
2017-06-20Author
Safari, Reza
van der Linden, Marietta
Mercer, Tom
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Safari, R., van der Linden, M. & Mercer, T. (2017) Effect of exercise interventions on perceived fatigue in people with multiple sclerosis: Synthesis of meta-analytic reviews. Neurodegenerative Disease Management, 7(3), pp. 219-230.
Abstract
Although exercise training has been advocated as a nonpharmacological treatment for
multiple sclerosis (MS) related fatigue, no consensus exists regarding its effectiveness. To
address this, we collated meta-analytic reviews that explored the effectiveness of exercise
training for the treatment of MS-related fatigue. We searched five online databases for
relevant reviews, published since 2005, and identified 172 records. Five reviews were
retained for systematic extraction of information and evidence quality analysis. Although
our review synthesis indicated that exercise training interventions have a moderate effect
on fatigue reduction in people with MS, no clear insight was obtained regarding the relative
effectiveness of specific types or modes of exercise intervention. Moreover, Grading of
Recommendation Assessment, Development and Evaluation revealed that the overall
quality of evidence emanating from these five reviews was 'very low'.