The Effect of Curcumin on Exercise Induced Oxidative Stress and Hypertension.
(2015) The Effect of Curcumin on Exercise Induced Oxidative Stress and Hypertension., no. 30.
Background - Many studies have been conducted in order to determine the antioxidant properties of curcumin on exercise induced oxidative stress and hypertension. By analysing the anti-inflammatory and antioxidant effects of curcumin, researchers have hypothesised that the supplement, given at a high enough dose, has the ability to lower oxidative stress and high blood pressure (BP) in hypertensive patients. Objectives - This study was carried out to investigate the effects of curcumin supplementation on exercise induced oxidative stress and BP in comparison to a placebo. The effects were measured through determination of antioxidants, polyphenols and lipid peroxidation, by analysing whether an increase in antioxidants would lower blood pressure and lipid peroxidation. Physical activity was investigated through assessing the effect curcumin would have on distance completed after a 30 minute run, before and after intervention. Methods - A randomized parallel placebo-controlled study was carried out to assess the effects of 500mg dose of curcumin on 20 healthy volunteers. The study took place for 11 days, 8 of which the participants were required to give three 24 hour urine samples; run for 30 minutes on day 2 and day 9 and take either curucmin supplement or placebo. Research was carried out through analysis of 24 hour urine samples, to detect the presence of oxidative stress markers. Blood pressure readings were taken as a baseline measurement, before and after the 30 minute run, with a final reading being taken on the last day of the trial. Laboratory analysis was carried out via FRAP assay, total phenols (Folins method) and TBARS assay. Results - No significant change was observed between basal and final systolic and diastolic blood pressure measurements in either intervention group however, a decrease in mean values was seen in the curucmin group (119.6 ± 12.7 to 114.9 ± 11.5) from basal to final measurements. A significant increase was witnessed in antioxidant concentrations pre and post intervention in the curcumin group (p=0.004). Similarly, polyphenol concentrations also increased however no statistical significance was obtained. TBARS assay detected a significant increase in lipid peroxidation in the curcumin group, post-intervention, indicating the presence of oxidative stress. Conclusion - This study concludes that curcumin possesses antioxidant properties which have proven to reduce hypertension caused by strenuous exercise. In depth analysis allowed us to detect an increase in antioxidants and polyphenols, which in turn resulted in a decrease in blood pressure, post intervention. With regards to oxidative stress, we are not fully aware as to why lipid peroxidation increased after the eight day intervention however; this provides indication that further research is required to assess the effects of curucmin on oxidative stress. Keywords - Hypertension, oxidative stress, curcumin, antioxidants, lipid peroxidation