Determining the relationship between hyperglycaemia and endothelial function in young healthy adults
(2015) Determining the relationship between hyperglycaemia and endothelial function in young healthy adults, no. 42.
Background: Evidence suggests that hyperglycaemia can cause endothelial dysfunction, increasing the risk of cardiovascular disease. Previous studies which have investigated oral glucose loading on endothelial function have generally focussed on older individuals with age-associated ailments; therefore little data exists in regards to these effects in younger, healthier adults. Furthermore, only a small number of these studies have used a non-glucose solution as an experimental control in order to rule out effects not directly attributable to glucose. Objective: To investigate the effects of hyperglycaemia on endothelial function in young, healthy adults. Methods: Using a single-blinded, within-subject study design, five healthy participants (3 male, 2 female), aged 21.6 ± 0.24 years old each consumed a glucose drink (75g glucose in 250ml water) and two non-glucose control drinks (1.5g of Canderel in 250ml water or 250ml of water alone) in a randomized order over three separate days. Endothelial function was measured by pulse wave velocity and augmentation index at baseline and at 30, 60 and 90 minutes after consumption of each drink. Blood and saliva samples were collected for the determination of glucose levels in addition to measurements of systolic blood pressure, diastolic blood pressure and heart rate at the same time points. Results: Blood glucose levels significantly increased at 30 minutes following consumption of the glucose drink (p>0.002) but no significant increase in blood glucose was evident at 60 and 90 minutes. Canderel and water did not significantly increase blood glucose levels, however none of the drinks led to a significant difference in salivary glucose. There were no significant differences in pulse wave velocity, augmentation index, diastolic blood pressure or heart rate within or between the drinks over 90 minutes. There were no significant differences in systolic blood pressure within the three drinks over 90 minutes. No significant differences in SBP were found between the three drinks at 30 or 90 minutes, however at 60 minutes, SBP following water was significantly higher compared Canderel (p=0.031). Conclusion: An oral glucose load of 75g did not have a significant effect on endothelial function, measured by pulse wave velocity and augmentation index, among a population of young healthy adults over a period of 90 minutes. Keywords: hyperglycaemia, endothelial function, pulse wave velocity, augmentation index, young healthy adults