The Institute for Global Health and Development
Permanent URI for this collectionhttps://eresearch.qmu.ac.uk/handle/20.500.12289/9
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Item Tuberculosis from transmission in clinics in high HIV settings may be far higher than contact data suggest(International Union Against Tuberculosis and Lung Disease, 2020-04-01) McCreesh, Nicky; Grant, Alison D.; Yates, Tom A.; Karat, Aaron S.; White, Richard G.Background: In South Africa, it is estimated that only 0.5-6% of people’s contacts occur in clinics. Both people with infectious tuberculosis and people with increased susceptibility to disease progression may spend more time in clinics however, increasing the importance of clinic-based transmission to overall disease incidence.Item Algorithm-guided empirical tuberculosis treatment for people with advanced HIV (TB Fast Track): An open-label, cluster-randomised trial(Elsevier, 2019-11-11) Grant, Alison D.; Charalambous, Salome; Tlali, Mpho; Karat, Aaron S.; Dorman, Susan E.; Hoffmann, Christopher J.; Johnson, Suzanne; Vassall, Anna; Churchyard, Gavin J.; Fielding, Katherine L.Background Tuberculosis, which is often undiagnosed, is the major cause of death among HIV-positive people. We aimed to test whether the use of a clinical algorithm enabling the initiation of empirical tuberculosis treatment by nurses in primary health-care clinics would reduce mortality compared with standard of care for adults with advanced HIV disease.